PP58

PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values.

Product Specifications

CAS Number

[212391-58-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

FGFR; PDGFR; Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PP58.html

Concentration

10mM

Purity

98.70

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

NCCOC1=CC=C(NC(N=C2N3C)=NC=C2C=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=C1

Molecular Formula

C22H19Cl2N5O2

Molecular Weight

456.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Wissing J, et al. Chemical Proteomic Analysis Reveals Alternative Modes of Action for Pyrido[2,3-d]pyrimidine Kinase Inhibitors. Mol Cell Proteomics. 2004 Dec;3 (12) :1181-93.|[2]Blencke S, et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol. 2004 May;11 (5) :691-701.