(R) -Pantetheine
(R) -Pantetheine is the biosynthetic precursor to CoA. (R) -Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA) . (R) -Pantetheine has high toxicity[1][2][3].
Product Specifications
CAS Number
496-65-1
Product Name Alternative
Pantetheine
UNSPSC
12352211
Hazard Statement
H301
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/r-pantetheine.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 66.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C([C@@H](C(C)(CO)C)O)NCCC(NCCS)=O
Molecular Formula
C11H22N2O4S
Molecular Weight
278.37
Precautions
H301
References & Citations
[1]Rothmann M, et al. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. J Am Chem Soc. 2013 Apr 24;135 (16) :5962-5.|[2]Wang Y, et al. Ligand supplementation restores the cancer therapy efficacy of an antirheumatic drug auranofin from serum inactivation. bioRxiv, 2024: 2024.01. 25.577173.|[3]Moretto L, et al. Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates. Chem Commun (Camb) . 2017 Oct 25;53 (83) :11457-11460.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
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