(R) -Pantetheine

(R) -Pantetheine is the biosynthetic precursor to CoA. (R) -Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA) . (R) -Pantetheine has high toxicity[1][2][3].

Product Specifications

CAS Number

[496-65-1]

Product Name Alternative

Pantetheine

UNSPSC

12352211

Hazard Statement

H301

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/r-pantetheine.html

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 66.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@H](C(C)(CO)C)O)NCCC(NCCS)=O

Molecular Formula

C11H22N2O4S

Molecular Weight

278.37

Precautions

H301

References & Citations

[1]Rothmann M, et al. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. J Am Chem Soc. 2013 Apr 24;135 (16) :5962-5.|[2]Wang Y, et al. Ligand supplementation restores the cancer therapy efficacy of an antirheumatic drug auranofin from serum inactivation. bioRxiv, 2024: 2024.01. 25.577173.|[3]Moretto L, et al. Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates. Chem Commun (Camb) . 2017 Oct 25;53 (83) :11457-11460.