CU-CPT22
CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41 µM. CU-CPT22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 µM[1].
Product Specifications
CAS Number
1416324-85-0
UNSPSC
12352005
Hazard Statement
H334, H410
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CU_CPT_22.html
Purity
99.0
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(C(C=C1O)=CC2=CC(OC)=C(O)C(O)=C2C1=O)OCCCCCC
Molecular Formula
C19H22O7
Molecular Weight
362.37
Precautions
H334, H410
References & Citations
[1]Cheng K, et al. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem Int Ed Engl. 2012 Dec 3;51 (49) :12246-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR1; TLR2
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Fusobacterium nucleatum subsp.nucleatum UPF0102 protein FN1370 (FN1370)
Recombinant Fusobacterium nucleatum subsp.nucleatum UPF0102 protein FN1370 (FN1370)
Recombinant Fusobacterium nucleatum subsp.nucleatum UPF0102 protein FN1370 (FN1370)