Cot inhibitor-3

Cot inhibitor-3 (Compound 33) is a potent and selective cancer osaka thyroid (COT) kinase inhibitor, with an IC50 of 4 nM. Cot inhibitor-3 can be used to prevent inflammation-driven lameness[1].

Product Specifications

CAS Number

[1984784-12-4]

UNSPSC

12352005

Target

MAP3K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cot-inhibitor-3.html

Smiles

C[C@H](CN1CCOCC1)NC2=NC3=C(C=C2)C=C(C=C3)N4C5=C(N=C4)C=NC6=CN=C(C7=CC=NC=C7)C=C56

Molecular Formula

C30H28N8O

Molecular Weight

516.60

References & Citations

[1]Glatthar R, et, al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59 (16) :7544-60.