Tri-GalNAc-DBCO

Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units linked to DBCO. Tri-GalNAc-DBCO can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing an azide group. Tri-GalNAc-DBCO specifically binds to the asialoglycoprotein receptor (ASGPR) . Tri-GalNAc-DBCO directs the conjugated molecule to the lysosome for degradation via receptor-mediated endocytosis. Tri-GalNAc-DBCO can be used in the study of liver-related diseases[1][2][3].

Product Specifications

CAS Number

[2999748-27-3]

UNSPSC

12352005

Target

Biochemical Assay Reagents; LYTACs

Type

Reference compound

Related Pathways

Others; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tri-galnac-dbco.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCCNC(CCCCO[C@H](O[C@@H]1CO)[C@@H]([C@H]([C@H]1O)O)NC(C)=O)=O)CCOCC(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]2CO)[C@@H]([C@H]([C@H]2O)O)NC(C)=O)=O)=O)(NC(CCCCC(N3CC4=CC=CC=C4C#CC5=CC=CC=C53)=O)=O)COCCC(NCCCNC(CCCCO[C@H](O[C@@H]6CO)[C@@H]([C@H]([C@H]6O)O)NC(C)=O)=O)=O

Molecular Formula

C82H127N11O29

Molecular Weight

1730.94

References & Citations

[1]Green Ahn, et al. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. Nat Chem Biol. 2021 Sep;17 (9) :937-946.|[2]Maity P , et al. Targeting the Epidermal Growth Factor Receptor with Molecular Degraders: State-of-the-Art and Future Opportunities. J Med Chem. 2023 Mar 9;66 (5) :3135-3172. |[3]Donahue TC, et al. Synthetic Site-Specific Antibody-Ligand Conjugates Promote Asialoglycoprotein Receptor-Mediated Degradation of Extracellular Human PCSK9. ACS Chem Biol. 2023 Jul 21;18 (7) :1611-1623.