E3 ligase Ligand 45
E3 ligase Ligand 45 is an E3 ligase ligand that can be used to synthesize the PROTAC degrader Setidegrasib for Ras[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-45.html
Smiles
O=C(N(C[C@@H]1O)[C@@H](C1)C(N[C@H](C2=CC=C(C(SC=N3)=C3C)C=C2)CO)=O)[C@@H](O)C(C)C
Molecular Formula
C22H29N3O5S
Molecular Weight
447.55
References & Citations
[1]Yoshinari, et al. Preparation of quinazoline-linked (4R) -4-hydroxy-L-prolinamide compounds for inducing degradation of G12D-mutation KRAS protein: World Intellectual Property Organization, WO2022173032[P]. 2022-08-18.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6325110-01 0.1 mL
NFKBIL1, ID (NFKBIL1, IKBL, NF-kappa-B inhibitor-like protein 1, Inhibitor of kappa B-like protein, Nuclear factor of kappa light polypeptide gene enhancer in B Cells inhibitor-like 1) (MaxLight 550)
Sign In for Pricing
View Details MBS6325110-02 5x 0.1 mL
NFKBIL1, ID (NFKBIL1, IKBL, NF-kappa-B inhibitor-like protein 1, Inhibitor of kappa B-like protein, Nuclear factor of kappa light polypeptide gene enhancer in B Cells inhibitor-like 1) (MaxLight 550)
Sign In for Pricing
View Details 