NG 52

NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p[1][2].

Product Specifications

CAS Number

[212779-48-1]

Product Name Alternative

Compound 52

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NG-52.html

Purity

99.88

Solubility

DMSO : 75 mg/mL (ultrasonic)

Smiles

ClC1=CC(NC2=NC(NCCO)=NC3=C2N=CN3C(C)C)=CC=C1

Molecular Formula

C16H19ClN6O

Molecular Weight

346.81

Precautions

H315, H319, H335

References & Citations

[1]ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281 (5376) :533-8.|[2]Wen-Liang Wang, et al. Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacol Sin. 2020 Jul 31.