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LX-1031

LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.

Product Specifications

CAS Number

[945976-76-1]

UNSPSC

12352005

Target

Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/LX-1031.html

Purity

99.14

Solubility

DMSO : ≥ 34 mg/mL

Smiles

NC1=NC(C2=CC=C(C=C2)C[C@@H](C(O)=O)N)=CC(O[C@H](C3=CC=C(C4=CC(OC)=CC=C4)C=C3)C(F)(F)F)=N1

Molecular Formula

C28H25F3N4O4

Molecular Weight

538.52

References & Citations

[1]Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23 (3) :193-200.|[2]Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. IDrugs. 2010 Dec;13 (12) :921-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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