Falcarinol

Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis[1]. Falcarinol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[21852-80-2]

Product Name Alternative

Panaxynol; Carotatoxin

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HSP

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/falcarinol.html

Concentration

40.92 mM * 100 μL in Ethanol

Purity

99.83

Solubility

10 mM in DMSO

Smiles

C=C[C@@H](O)C#CC#CC/C=C\CCCCCCC

Molecular Formula

C17H24O

Molecular Weight

244.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Le HT, et al. Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells. Cancer Lett. 2018 Jan 1;412:297-307.