2'-Deoxyuridine

2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411) . 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) [1][2][3].

Product Specifications

CAS Number

[951-78-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Thymidylate Synthase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/2_acute_-Deoxyuridine.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N1)N([C@H]2C[C@H](O)[C@@H](CO)O2)C=CC1=O

Molecular Formula

C9H12N2O5

Molecular Weight

228.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26 (1) :1-5.|[2]Ashraf Saad Rasheed, et al. Development of ZIC-HILIC methods using ultraviolet detection for determining 2-deoxyuridine in human serum[J]. Systematic Reviews in Pharmacy. 2020 March; 11 (2) :388-394.|[3]Liu M, et al. Thymidine and 2'-deoxyuridine reduce microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury[J]. Arch Biochem Biophys. 2022 Oct 30;729:109377.