Cyclovalone

Cyclovalone (Beveno) is a synthetic curcumin derivate, which inihibits cyclooxygenase and exhibits anti-inflammatory, antitumor and antioxidant activities[1]. Cyclovalone inhibits cell proliferation in normal and malignant prostatic cells. Cyclovalone ist orally active[2].

Product Specifications

CAS Number

[579-23-7]

Product Name Alternative

Beveno

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cyclovalone.html

Purity

90.0

Solubility

10 mM in DMSO

Smiles

O=C(/C(CCC/1)=C/C2=CC(OC)=C(O)C=C2)C1=C\C3=CC(OC)=C(O)C=C3

Molecular Formula

C22H22O5

Molecular Weight

366.41

References & Citations

[1]Itokawa H, et al., Recent advances in the investigation of curcuminoids. Chin Med. 2008 Sep 17;3:11.|[2]Markaverich BM, et al., Type II [3H]estradiol binding site antagonists: inhibition of normal and malignant prostate cell growth and proliferation. Int J Oncol. 1998 May;12 (5) :1127-35.