AXL-IN-13

AXL-IN-13 is a potent and orally active AXL inhibitor (IC50: 1.6 nM, Kd: 0.26 nM) . AXL-IN-13 reverses TGF-β1-induced epithelial-mesenchymal transition (EMT), and inhibits cancer cell migration and invasion[1].

Product Specifications

CAS Number

[2376928-82-2]

UNSPSC

12352005

Target

FLT3; PDGFR; TAM Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/axl-in-13.html

Purity

98.03

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(C=C(C2=C1)N=CC=C2OC3=C(C=C(C=C3)NC4=NN(C=C4C(NC5CCCCC5)=O)C)F)OCCCN6CCOCC6

Molecular Formula

C34H41FN6O5

Molecular Weight

632.72

References & Citations

[1]Chan S, et al. Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors. J Med Chem. 2022 Nov 24;65 (22) :15374-15390.