TB22
Product Specifications
UNSPSC Description
TB22 is a non-nucleoside inhibitor of DOT1LR231Q, possessing anticancer activity. TB22 inhibits the malignant phenotype of lung cancer cells carrying the R231Q mutation through the MAPK/ERK signaling pathway, and can be used for lung cancer research[1].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tb22.html
Smiles
CC(C1=CC=C(C=C1)NC(NCCCN(CCCN2CCOCC2)CC3(O)CN(CC3)C4=NC(Cl)=NC5=C4C=CS5)=O)(C)C
Molecular Weight
644.27
References & Citations
[1]Tan Z, et al. Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162939/TB22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162939/
Clinical Information
No Development Reported
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