CFTR (inh) -172

CFTR (inh) -172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.

Product Specifications

CAS Number

[307510-92-5]

UNSPSC

12352005

Hazard Statement

H302, H319, H372, H410

Target

Autophagy; CFTR

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/CFTR_inh_-172.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

S=C(S/1)N(C2=CC=CC(C(F)(F)F)=C2)C(C1=C\C3=CC=C(C=C3)C(O)=O)=O

Molecular Formula

C18H10F3NO3S2

Molecular Weight

409.40

Precautions

H302, H319, H372, H410

References & Citations

[1]Ma T, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec;110 (11) :1651-8.|[2]Taddei A, et al. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 2004 Jan 30;558 (1-3) :52-6.