CFTR(inh)-172
Product Specifications
UNSPSC Description
CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.
Target Antigen
Autophagy; CFTR
Type
Reference compound
Related Pathways
Autophagy;Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/CFTR_inh_-172.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
S=C(S/1)N(C2=CC=CC(C(F)(F)F)=C2)C(C1=C\C3=CC=C(C=C3)C(O)=O)=O
Molecular Weight
409.40
References & Citations
[1]Ma T, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec;110(11):1651-8.|[2]Taddei A, et al. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 2004 Jan 30;558(1-3):52-6.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16671/CFTR-inh-172-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16671/CFTR-inh-172-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
307510-92-5
Available Sizes
Curated Selection
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