Go6976

Go6976 is a Protein Kinase C (PKC) inhibitor, with an IC50 of 20 nM.

Product Specifications

CAS Number

[136194-77-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Influenza Virus; PKC

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Go_6976.html

Purity

99.57

Solubility

DMSO : 65 mg/mL (ultrasonic)

Smiles

N#CCCN(C1=C2C(CNC3=O)=C3C4=C1N(C)C5=C4C=CC=C5)C6=C2C=CC=C6

Molecular Formula

C24H18N4O

Molecular Weight

378.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Qatsha KA, et al. Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. Proc Natl Acad Sci U S A. 1993 May 15;90 (10) :4674-8.|[2]Hayamitsu Adachi, et al. Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology. The Journal of Antibiotics volume 71, pages 60–71 (2018) .|[3]Mahmoudian S, et al. Influenza A virus proteins PB1 and NS1 are subject to functionally important phosphorylation by protein kinase C. J Gen Virol. 2009;90 (Pt 6) :1392-1397.