Go6976
Product Specifications
UNSPSC Description
Go6976 is a Protein Kinase C (PKC) inhibitor, with an IC50 of 20 nM.
Target Antigen
Influenza Virus; PKC
Type
Reference compound
Related Pathways
Anti-infection;Epigenetics;TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Go_6976.html
Purity
99.83
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CCCN(C1=C2C(CNC3=O)=C3C4=C1N(C)C5=C4C=CC=C5)C6=C2C=CC=C6
Molecular Weight
378.43
References & Citations
[1]Qatsha KA, et al. Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4674-8.|[2]Hayamitsu Adachi, et al. Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology. The Journal of Antibiotics volume 71, pages 60–71 (2018).|[3]Mahmoudian S, et al. Influenza A virus proteins PB1 and NS1 are subject to functionally important phosphorylation by protein kinase C. J Gen Virol. 2009;90(Pt 6):1392-1397.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10183/Go6976-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10183/Go6976-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
136194-77-9
Available Sizes
Curated Selection
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