XO44
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK2 and CDK1. XO44 also labels CDK4 proteins in cells[1][2].
Product Specifications
CAS Number
2088112-70-1
Product Name Alternative
PF-6808472
UNSPSC
12352005
Hazard Statement
H314
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xo44.html
Purity
99.38
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(CN2CCN(C3=NC(C(NCC#C)=O)=CC(NC4=NNC(C5CC5)=C4)=N3)CC2)C=C1)(F)=O
Molecular Formula
C25H27FN8O3S
Molecular Weight
538.60
Precautions
H314
References & Citations
[1]Kevin D Freeman-Cook, et al. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J Med Chem. 2021 Jul 8;64 (13) :9056-9077.|[2]Guiley KZ, et al. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 Dec 13;366 (6471) :eaaw2106.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4
Available Sizes
Frequently Asked Questions
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