XO44

XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK2 and CDK1. XO44 also labels CDK4 proteins in cells[1][2].

Product Specifications

CAS Number

[2088112-70-1]

Product Name Alternative

PF-6808472

UNSPSC

12352005

Hazard Statement

H314

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xo44.html

Purity

99.38

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(CN2CCN(C3=NC(C(NCC#C)=O)=CC(NC4=NNC(C5CC5)=C4)=N3)CC2)C=C1)(F)=O

Molecular Formula

C25H27FN8O3S

Molecular Weight

538.60

Precautions

H314

References & Citations

[1]Kevin D Freeman-Cook, et al. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J Med Chem. 2021 Jul 8;64 (13) :9056-9077.|[2]Guiley KZ, et al. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 Dec 13;366 (6471) :eaaw2106.