BLK degrader 1

BLK degrader 1 (compound 9) is a selective degrader of B-lymphoid tyrosine kinase (BLK) . BLK degrader 1 shows anticancer activity in several B-lymphoid cell lines[1].

Product Specifications

CAS Number

[3049215-64-4]

UNSPSC

12352005

Target

Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/blk-degrader-1.html

Purity

98.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1C(NC2=CN=C(N=C2)NC3=CC=CC(N)=C3)=O)NC(C4=CC=C(C=C4)C5=CC(C(F)(F)F)=CC=C5)=O

Molecular Formula

C32H25F3N6O2

Molecular Weight

582.58

References & Citations

[1]Fu T, et al. Discovery of 2,5-diaminopyrimidine derivatives as the first series of selective monomeric degraders of B-lymphoid tyrosine kinase. Eur J Med Chem. 2023 Aug 5;256:115460.