BLK degrader 1
BLK degrader 1 (compound 9) is a selective degrader of B-lymphoid tyrosine kinase (BLK) . BLK degrader 1 shows anticancer activity in several B-lymphoid cell lines[1].
Product Specifications
CAS Number
[3049215-64-4]
UNSPSC
12352005
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/blk-degrader-1.html
Purity
98.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=C(C=C1C(NC2=CN=C(N=C2)NC3=CC=CC(N)=C3)=O)NC(C4=CC=C(C=C4)C5=CC(C(F)(F)F)=CC=C5)=O
Molecular Formula
C32H25F3N6O2
Molecular Weight
582.58
References & Citations
[1]Fu T, et al. Discovery of 2,5-diaminopyrimidine derivatives as the first series of selective monomeric degraders of B-lymphoid tyrosine kinase. Eur J Med Chem. 2023 Aug 5;256:115460.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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