CCG215022
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, GRK5 and GRK1, respectively.
Product Specifications
CAS Number
1813527-81-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
G Protein-coupled Receptor Kinase (GRK) ; PKA
Type
Reference compound
Related Pathways
GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCG215022.html
Purity
99.79
Solubility
DMSO : ≥ 28 mg/mL
Smiles
CC(N1)=C(C(NC2=CC=C(NN=C3)C3=C2)=O)C(C4=CC(C(NCC5=CC=CC=N5)=O)=C(F)C=C4)NC1=O
Molecular Formula
C26H22FN7O3
Molecular Weight
499.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Homan KT, et al. Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally DesignedInhibitor. J Biol Chem. 2015 Aug 21;290 (34) :20649-59.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GRK2
Available Sizes
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