Floctafenine

Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent[1][2]. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro, showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research[3].

Product Specifications

CAS Number

[23779-99-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/floctafenine.html

Purity

94.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OCC(O)CO)C1=CC=CC=C1NC2=CC=NC3=C(C(F)(F)F)C=CC=C23

Molecular Formula

C20H17F3N2O4

Molecular Weight

406.36

Precautions

H315, H319, H320

References & Citations

[1]P Giuseppe, et al. Floctafenine: a valid alternative in patients with adverse reactions to nonsteroidal anti-inflammatory drugs. Ann Allergy Asthma Immunol. 1997 Jan;78 (1) :74-8.|[2]Gehan Hegazy Hegazy, et al. Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity. Arch Pharm (Weinheim) . 2005 Aug;338 (8) :378-84.|[3]R Maenthaisong, et al. Clinical pharmacology of cyclooxygenase inhibition and pharmacodynamic interaction with aspirin by floctafenine in Thai healthy subjects.Int J Immunopathol Pharmacol. Apr-Jun 2013;26 (2) :403-17.