CL 218872
CL 218872 is an orally active and selective ligand for the benzodiazepine receptor subtype BZ1. CL 218872 exhibits anxiolytic, sedative and anticonvulsant activities. CL 218872 can be used in researches of anxiety related disorders and epilepsy[1][2][3][4][5].
Product Specifications
CAS Number
66548-69-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cl-218872.html
Purity
99.25
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(C1=CC(C2=NN3C(C=C2)=NN=C3C)=CC=C1)(F)F
Molecular Formula
C13H9F3N4
Molecular Weight
278.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Squires RF, et al. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol Biochem Behav. 1979 May;10 (5) :825-30. |[2]Oakley NR, et al. The benzodiazepine receptor ligand CL218,872 has both anxiolytic and sedative properties in rodents. Neuropharmacology. 1984 Jul;23 (7A) :797-802.|[3]File SE, et al. The sedative effects of CL 218,872, like those of chlordiazepoxide, are reversed by benzodiazepine antagonists. Psychopharmacology (Berl) . 1985;85 (3) :295-300. |[4]Gee KW, et al. CL 218872 antagonism of diazepam induced loss of righting reflex: evidence for partial agonistic activity at the benzodiazepine receptor. Life Sci. 1983 Feb 28;32 (9) :1037-40.|[5]McNamara RK, et al. Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze. Psychopharmacology (Berl) . 1992;107 (2-3) :347-51.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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