XIE62-1004-A
XIE62-1004-A is an inducer of p62-LC3 interaction. XIE62-1004-A can bind to the ZZ-domain of p62, inducing p62 oligomerization and activating p62-dependent autophagy[1].
Product Specifications
CAS Number
[2421146-32-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Atg8/LC3; Autophagy; p62
Type
Reference compound
Related Pathways
Autophagy
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/xie62-1004-a.html
Purity
99.89
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OCCNCC1=CC=C(C(OCC2=CC=CC=C2)=C1)OCC3=CC=CC=C3.Cl
Molecular Formula
C23H26ClNO3
Molecular Weight
399.91
Precautions
H302, H315, H319
References & Citations
[1]Horos R, et al. The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy. Cell. 2019;176 (5) :1054-1067.e12.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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DDR1, NT (Epithelial Discoidin Domain-containing Receptor 1, Epithelial Discoidin Domain Receptor 1, Tyrosine Kinase DDR, Discoidin Receptor Tyrosine Kinase, Tyrosine-protein Kinase CAK, Cell Adhesion Kinase, TRK E, Protein-tyrosine Kinase 3A, Protein-tyr
