RU-SKI 43 (hydrochloride)
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity[1].
Product Specifications
CAS Number
1782573-67-4
UNSPSC
12352005
Target
Hedgehog
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RU-SKI-43-hydrochloride.html
Purity
98.81
Solubility
DMSO : ≥ 51 mg/mL|H2O : 2.5 mg/mL (ultrasonic)
Smiles
[H]Cl.O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3
Molecular Formula
C22H31ClN2O2S
Molecular Weight
423.01
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Exp Cell Res. 2024 Jun 1;439 (1) :114072.|Dent J (Basel) . 2024 Apr 15;12 (4) :108.
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