Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

RU-SKI 43 (hydrochloride)

RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity[1].

Product Specifications

CAS Number

1782573-67-4

UNSPSC

12352005

Target

Hedgehog

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RU-SKI-43-hydrochloride.html

Purity

98.81

Solubility

DMSO : ≥ 51 mg/mL|H2O : 2.5 mg/mL (ultrasonic)

Smiles

[H]Cl.O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3

Molecular Formula

C22H31ClN2O2S

Molecular Weight

423.01

References & Citations

[1]Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575.|[2]Petrova E, et al. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.Nat Chem Biol. 2013 Apr;9 (4) :247-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Exp Cell Res. 2024 Jun 1;439 (1) :114072.|Dent J (Basel) . 2024 Apr 15;12 (4) :108.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

IRF2BP1 Rabbit Polyclonal Antibody
TA368563 100 µL

IRF2BP1 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
CYB5D2 (C-term) Rabbit Polyclonal Antibody
AP51155PU-N 400 µL

CYB5D2 (C-term) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
PE/Cyanine7 Anti-Mouse CD86 Antibody[GL-1]
E-AB-F0994UH-01 25 µg

PE/Cyanine7 Anti-Mouse CD86 Antibody[GL-1]

Sign In for Pricing
View Details
PE/Cyanine7 Anti-Mouse CD86 Antibody[GL-1]
E-AB-F0994UH-02 100 µg

PE/Cyanine7 Anti-Mouse CD86 Antibody[GL-1]

Sign In for Pricing
View Details
rac-Hesperetin 3’,7-Diglucuronide
TRC-H289535-10MG 10 mg

rac-Hesperetin 3’,7-Diglucuronide

Sign In for Pricing
View Details
Tissue FFPE Sections, Prostate
CS803182 5x 5 µm

Tissue FFPE Sections, Prostate

Sign In for Pricing
View Details