RU-SKI 43 (hydrochloride)

RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity[1].

Product Specifications

CAS Number

[1782573-67-4]

UNSPSC

12352005

Target

Hedgehog

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RU-SKI-43-hydrochloride.html

Purity

98.81

Solubility

DMSO : ≥ 51 mg/mL|H2O : 2.5 mg/mL (ultrasonic)

Smiles

[H]Cl.O=C(CNCC(C)CC)N1CCC2=C(C=CS2)C1COC3=CC=CC(C)=C3

Molecular Formula

C22H31ClN2O2S

Molecular Weight

423.01

References & Citations

[1]Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575.|[2]Petrova E, et al. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.Nat Chem Biol. 2013 Apr;9 (4) :247-9.