Xaliproden (hydrochloride)

Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM) . Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM) . Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases[1][2][3].

Product Specifications

CAS Number

[90494-79-4]

Product Name Alternative

SR57746A; SR57746 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/xaliproden-hydrochloride.html

Concentration

10mM

Purity

98.57

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

FC(C1=CC(C2=CCN(CCC3=CC=C4C=CC=CC4=C3)CC2)=CC=C1)(F)F.[H]Cl

Molecular Formula

C24H23ClF3N

Molecular Weight

417.89

Precautions

H302

References & Citations

[1]Cervo L, et, al. Potential antidepressant properties of SR 57746A, a novel compound with selectivity and high affinity for 5-HT1A receptors. Eur J Pharmacol. 1994 Feb 21; 253 (1-2) : 139-47.|[2]Simiand J, et, al. Neuropsychopharmacological profile in rodents of SR 57746A, a new, potent 5-HT1A receptor agonist. Fundam Clin Pharmacol. 1993;7 (8) :413-27.|[3]Fournier J, et, al. Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience. 1993 Aug; 55 (3) : 629-41.