GSK2256098

GSK2256098 is a selective FAK kinase inhibitor, which inhibits growth and survival of pancreatic ductal adenocarcinoma cells.

Product Specifications

CAS Number

[1224887-10-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; FAK

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GSK2256098.html

Purity

99.62

Solubility

DMSO : ≥ 30 mg/mL

Smiles

O=C(NOC)C1=CC=CC=C1NC2=CC(NC3=CC(C)=NN3C(C)C)=NC=C2Cl

Molecular Formula

C20H23ClN6O2

Molecular Weight

414.89

Precautions

H315, H319, H335

References & Citations

[1]Zhang J, et al. A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle. 2014;13 (19) :3143-9.|[2]Thanapprapasr D, et al. PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer. Mol Cancer Ther. 2015 Jun;14 (6) :1466-75.