SBI-0206965
Product Specifications
UNSPSC Description
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2[1].
Target Antigen
Apoptosis; Autophagy; ULK
Type
Reference compound
Related Pathways
Apoptosis;Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SBI-0206965.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CNC(C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br)=O
Molecular Weight
489.32
References & Citations
[1]Lu J, et al. Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell RenalCarcinoma and the Antitumor Effects of SBI-0206965. EBioMedicine. 2018 Aug;34:85-93.|[2]Egan DF, et al. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Mol Cell. 2015 Jul 16;59(2):285-97.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16966/SBI-0206965-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16966/SBI-0206965-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1884220-36-3
Available Sizes
Curated Selection
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