SBI-0206965

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation[1][2][3].

Product Specifications

CAS Number

[1884220-36-3]

UNSPSC

12352005

Hazard Statement

H302

Target

AMPK; Apoptosis; Autophagy; ULK

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SBI-0206965.html

Purity

99.92

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CNC(C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br)=O

Molecular Formula

C21H21BrN4O5

Molecular Weight

489.32

Precautions

H302

References & Citations

[1]Lu J, et al. Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell RenalCarcinoma and the Antitumor Effects of SBI-0206965. EBioMedicine. 2018 Aug;34:85-93.|[2]Egan DF, et al. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Mol Cell. 2015 Jul 16;59 (2) :285-97.|[3]Hawley SA, et al. BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation. Int J Mol Sci. 2023 Dec 29;25 (1) :453.