SBI-0206965
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation[1][2][3].
Product Specifications
CAS Number
1884220-36-3
UNSPSC
12352005
Hazard Statement
H302
Target
AMPK; Apoptosis; Autophagy; ULK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SBI-0206965.html
Purity
99.92
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CNC(C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br)=O
Molecular Formula
C21H21BrN4O5
Molecular Weight
489.32
Precautions
H302
References & Citations
[1]Lu J, et al. Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell RenalCarcinoma and the Antitumor Effects of SBI-0206965. EBioMedicine. 2018 Aug;34:85-93.|[2]Egan DF, et al. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Mol Cell. 2015 Jul 16;59 (2) :285-97.|[3]Hawley SA, et al. BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation. Int J Mol Sci. 2023 Dec 29;25 (1) :453.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ULK1; ULK2
Available Sizes
Frequently Asked Questions
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