TG100-115
TG100-115 is a selective PI3Kγ/PI3Kδ inhibitor with IC50s of 83 and 235 nM, respectively.
Product Specifications
CAS Number
677297-51-7
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/TG100-115.html
Purity
99.41
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)
Smiles
NC1=C(C(N=C2C3=CC(O)=CC=C3)=NC(N)=N1)N=C2C4=CC(O)=CC=C4
Molecular Formula
C18H14N6O2
Molecular Weight
346.34
Precautions
H302, H312, H332
References & Citations
[1]Doukas J, et al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103 (52) :19866-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PI3Kγ; PI3Kδ
Available Sizes
Frequently Asked Questions
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