Gly-Gly-Phe-Gly-NH-O-CO-Exatecan (hydrochloride)

Gly-Gly-Phe-Gly-NH-O-CO-Exatecan, as a drug-linker conjugate composed of linker Gly-Gly-Phe-Gly-NH-O-CO and Exatecan, can be used to prepare antibody conjugate drugs. Exatecan is a DNA topoisomerase I inhibitor that can be used in cancer research[1][2].

Product Specifications

CAS Number

[3053688-78-8]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gly-gly-phe-gly-nh-o-co-exatecan-hydrochloride.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(F)C=C2C3=C1CC[C@H](NC(COCNC(CNC([C@H](CC4=CC=CC=C4)NC(CNC(CN)=O)=O)=O)=O)=O)C3=C5C(C(N6C5)=CC([C@@](O)(CC)C(OC7)=O)=C7C6=O)=N2.Cl

Molecular Formula

C42H46ClFN8O10

Molecular Weight

877.31

References & Citations

[1]Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997;72 (4) :680-686.|[2]Thomas A, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016;17 (6) :e254-e262.