Tie2 kinase inhibitor 1

Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2].

Product Specifications

CAS Number

[948557-43-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Tie

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tie2-kinase-inhibitor-1.html

Purity

99.80

Solubility

DMSO : 17.86 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C5C=C(OC)C=CC5=C4)N2)C=C1)C

Molecular Formula

C26H21N3O2S

Molecular Weight

439.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Semones M, et al. Pyridinylimidazole inhibitors of Tie2 kinase. Bioorg Med Chem Lett. 2007 Sep 1;17 (17) :4756-60. Epub 2007 Jun 27.|[2]Hasenstein JR, et al. Efficacy of Tie2 receptor antagonism in angiosarcoma. Neoplasia. 2012 Feb;14 (2) :131-40.