Tie2 kinase inhibitor 1
Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2].
Product Specifications
CAS Number
[948557-43-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Tie
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tie2-kinase-inhibitor-1.html
Purity
99.80
Solubility
DMSO : 17.86 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C5C=C(OC)C=CC5=C4)N2)C=C1)C
Molecular Formula
C26H21N3O2S
Molecular Weight
439.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Semones M, et al. Pyridinylimidazole inhibitors of Tie2 kinase. Bioorg Med Chem Lett. 2007 Sep 1;17 (17) :4756-60. Epub 2007 Jun 27.|[2]Hasenstein JR, et al. Efficacy of Tie2 receptor antagonism in angiosarcoma. Neoplasia. 2012 Feb;14 (2) :131-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Tie2
Available Sizes
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