DX3-213B

DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor (IC50=3.6 nM) . DX3-213B impairs ATP generation (IC50=11 nM), and blocks MIA PaCa-2 cell growth (GI50=11 nM) . DX3-213B is used for the research of the pancreatic cancer[1].

Product Specifications

CAS Number

[2749555-66-4]

UNSPSC

12352005

Target

Mitochondrial Metabolism; Oxidative Phosphorylation

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dx3-213b.html

Concentration

10mM

Purity

99.68

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=S(N1C[C@@H](CCC1)C(N2CCC(F)(CC2)F)=O)(C3=CC=C(C=C3)S(C(C)C)(=O)=O)=O

Molecular Formula

C20H28F2N2O5S2

Molecular Weight

478.57

References & Citations

[1]Xue D, et al. Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer. J Med Chem. 2022;65 (4) :3404-3419.