β-catenin-IN-37

β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC50 values of 20 μM and 31 μM, respectively[1].

Product Specifications

CAS Number

[1783856-40-5]

Product Name Alternative

CP 526555 (dihydrochloride)

UNSPSC

12352005

Target

Wnt; β-catenin

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/β-catenin-in-37.html

Purity

99.13

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N1(CCC2=NNN=N2)C3=NC4=NON=C4N=C3C5=C1C=CC=C5

Molecular Formula

C13H9N9O

Molecular Weight

307.27

References & Citations

[1]Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58 (11) :4678-4692.