FR183998 free base

FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.

Product Specifications

CAS Number

[239440-20-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Na+/H+ Exchanger (NHE)

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/FR183998_free_base.html

Purity

98.00

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C2=C(Cl)SC(Cl)=C2)=CC(C(NCCN(C)C)=O)=C1)NC(N)=N

Molecular Formula

C17H19Cl2N5O2S

Molecular Weight

428.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ohara F, et al. Preischemic and postischemic treatment with a new Na+/H+-exchange inhibitor, FR183998, shows cardioprotective effects in rats with cardiac ischemia and reperfusion. J Cardiovasc Pharmacol. 1999 Dec;34 (6) :848-56.|[2]Ishizaki M, et al. Protective effect of FR183998, a Na+/H+ exchanger inhibitor, and its inhibition of iNOS induction in hepatic ischemia-reperfusion injury in rats. Shock. 2008 Sep;30 (3) :311-7.