SHP2-D26
SHP2-D26 is a first, potent and effective SHP2 PROTAC degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent. SHP2-D26 can be used for the study of esophageal cancer and acute myeloid leukemia (Pink: SHP2 ligand ; Blue: VHL ligand (HY-150803) ; Black: linker).
Product Specifications
CAS Number
2458219-65-1
UNSPSC
12352005
Target
Phosphatase; PROTACs; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-d26.html
Purity
95.83
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(CCC(N(CC4)CCN4CCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)=O
Molecular Formula
C56H79ClN12O6S2
Molecular Weight
1115.89
References & Citations
[1]Wang M, et al. Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein [published correction appears in J Med Chem. 2021 Jan 14;64 (1) :906-908]. J Med Chem. 2020;63 (14) :7510-7528.|[2]Wang M, et al. Correction to "Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein". J Med Chem. 2021 Jan 14;64 (1) :906-908.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TL519095V 500 µL Each
Ccl11 Mouse shRNA Lentiviral Particle (Locus ID 20292)
Sign In for Pricing
View Details 
PKSM040627 50 µg
Recombinant Mouse SynCam/CADM1 Protein (aa 1-377, His Tag)
Sign In for Pricing
View Details