SHP2-D26
SHP2-D26 is a first, potent and effective SHP2 PROTAC degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent. SHP2-D26 can be used for the study of esophageal cancer and acute myeloid leukemia (Pink: SHP2 ligand ; Blue: VHL ligand (HY-150803) ; Black: linker).
Product Specifications
CAS Number
2458219-65-1
UNSPSC
12352005
Target
Phosphatase; PROTACs; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-d26.html
Purity
95.83
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(CCC(N(CC4)CCN4CCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)=O
Molecular Formula
C56H79ClN12O6S2
Molecular Weight
1115.89
References & Citations
[1]Wang M, et al. Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein [published correction appears in J Med Chem. 2021 Jan 14;64 (1) :906-908]. J Med Chem. 2020;63 (14) :7510-7528.|[2]Wang M, et al. Correction to "Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein". J Med Chem. 2021 Jan 14;64 (1) :906-908.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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