SHP2-D26

SHP2-D26 is a first, potent and effective SHP2 PROTAC degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent. SHP2-D26 can be used for the study of esophageal cancer and acute myeloid leukemia (Pink: SHP2 ligand (HY-176797) ; Blue: VHL ligand (HY-150803) ; Black: linker) [1].

Product Specifications

CAS Number

[2458219-65-1]

UNSPSC

12352005

Target

Phosphatase; PROTACs; SHP2

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-d26.html

Purity

95.83

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(CCC(N(CC4)CCN4CCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)=O

Molecular Formula

C56H79ClN12O6S2

Molecular Weight

1115.89

References & Citations

[1]Wang M, et al. Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein [published correction appears in J Med Chem. 2021 Jan 14;64 (1) :906-908]. J Med Chem. 2020;63 (14) :7510-7528.|[2]Wang M, et al. Correction to "Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein". J Med Chem. 2021 Jan 14;64 (1) :906-908.