Isoimperatorin
Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.
Product Specifications
CAS Number
482-45-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Anti-infection; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Isoimperatorin.html
Concentration
10mM
Purity
99.61
Solubility
DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 6.25 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=C(OC/C=C(C)/C)C3=C(OC=C3)C=C2O1
Molecular Formula
C16H14O4
Molecular Weight
270.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25 (6) :856-9.|[2]Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21 (10) . pii: E1276.|[3]Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11 (7) :e0158796.|[4]Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7088934 Inquire
Recombinant Prochlorococcus marinus subsp. pastoris Protein CrcB homolog 2 (crcB2), partial
Sign In for Pricing
View Details 10950090-AAT 100 Tests
IFluor® 555 Anti-human CD95 Antibody *EOS9.1*
Sign In for Pricing
View Details LV661941 1.0 µg DNA
EMR1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)
Sign In for Pricing
View Details 
