Isoimperatorin
Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.
Product Specifications
CAS Number
482-45-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Anti-infection; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Isoimperatorin.html
Concentration
10mM
Purity
99.61
Solubility
DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 6.25 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=C(OC/C=C(C)/C)C3=C(OC=C3)C=C2O1
Molecular Formula
C16H14O4
Molecular Weight
270.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25 (6) :856-9.|[2]Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21 (10) . pii: E1276.|[3]Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11 (7) :e0158796.|[4]Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE
Available Sizes
Frequently Asked Questions
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