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Isoimperatorin

Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.

Product Specifications

CAS Number

[482-45-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Cholinesterase (ChE)

Type

Natural Products

Related Pathways

Anti-infection; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Isoimperatorin.html

Concentration

10mM

Purity

99.61

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 6.25 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=C(OC/C=C(C)/C)C3=C(OC=C3)C=C2O1

Molecular Formula

C16H14O4

Molecular Weight

270.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25 (6) :856-9.|[2]Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21 (10) . pii: E1276.|[3]Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11 (7) :e0158796.|[4]Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

AChE

Available Sizes

Curated Selection

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