Endo CNTinh-03
Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC50 is 4 μM) . Endo CNTinh-03 inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model[1].
Product Specifications
CAS Number
345288-49-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/endo-cntinh-03.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC(C2C(C3CCC2C3)C(O)=O)=O)SC(C)=C1C4=CC=C(C)C=C4)OC
Molecular Formula
C23H25NO5S
Molecular Weight
427.51
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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