Endo CNTinh-03

Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC50 is 4 μM) . Endo CNTinh-03 inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model[1].

Product Specifications

CAS Number

[345288-49-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/endo-cntinh-03.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

O=C(C1=C(NC(C2C(C3CCC2C3)C(O)=O)=O)SC(C)=C1C4=CC=C(C)C=C4)OC

Molecular Formula

C23H25NO5S

Molecular Weight

427.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Tradtrantip L, et al., Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion. Mol Pharmacol. 2009 Jan;75 (1) :134-42.