ZM 449829
ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3[1].
Product Specifications
CAS Number
[4452-06-6]
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
EGFR; JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zm-449829.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CC(C1=CC=C2C=CC=CC2=C1)=O
Molecular Formula
C13H10O
Molecular Weight
182.22
Precautions
H301, H311, H331, H341
References & Citations
[1]Brown GR, et, al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 2010 (6) 575-9.|[2]Orange JS, et, al. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J Clin Invest. 2011 Apr; 121 (4) : 1535-48.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; JAK1; JAK3
Available Sizes
Curated Selection
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