ZM 449829

ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3[1].

Product Specifications

CAS Number

[4452-06-6]

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H341

Target

EGFR; JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/zm-449829.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=CC(C1=CC=C2C=CC=CC2=C1)=O

Molecular Formula

C13H10O

Molecular Weight

182.22

Precautions

H301, H311, H331, H341

References & Citations

[1]Brown GR, et, al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 2010 (6) 575-9.|[2]Orange JS, et, al. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J Clin Invest. 2011 Apr; 121 (4) : 1535-48.