Pyridaben

Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria) . Pyridaben also significantly inhibits rat mitochondrial mtNOS function[1][2].

Product Specifications

CAS Number

[96489-71-3]

UNSPSC

12352005

Hazard Statement

H301+H331-H410

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pyridaben.html

Concentration

10mM

Purity

99.27

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(Cl)=C(SCC2=CC=C(C(C)(C)C)C=C2)C=NN1C(C)(C)C

Molecular Formula

C19H25ClN2OS

Molecular Weight

364.93

Precautions

P261-P264-P270-P271-P273-P304+P340-P330-P391-P403+P233-P405-P501

References & Citations

[1]Gomez C, et al. Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci. 2007 Jan 1;12:1079-93. |[2]Namin HH, et al. Resistance to pyridaben in Canadian greenhouse populations of two-spotted spider mites, Tetranychus urticae (Koch) . Pestic Biochem Physiol. 2020 Nov;170:104677.