Thalidomide-O-COOH

Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs[1].

Product Specifications

CAS Number

[1061605-21-7]

Product Name Alternative

Cereblon ligand 3; E3 ligase Ligand 3

UNSPSC

12352005

Hazard Statement

H301, H312, H360

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/E3_ligase_Ligand_3.html

Purity

99.85

Solubility

DMSO : ≥ 42 mg/mL

Smiles

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(O)=O

Molecular Formula

C15H12N2O7

Molecular Weight

332.27

Precautions

H301, H312, H360

References & Citations

[1]Bozilovic J, et al. Novel, highly potent PROTACs targeting AURORA-A kinase. Current Research in Chemical Biology. 2022, 2: 100032.|[2]Yamanaka S, et al. Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation. Nat Commun. 2023 Aug 18;14 (1) :4683.