Mouse TREM-1 SCHOOL peptide

Mouse TREM-1 SCHOOL peptide (Mouse TREM-1 (213-221), GF9) targets the interaction between TREM-1 and its signaling partner DAP-12, specifically silencing the TREM-1 signaling pathway, regulate the production of TREM-1-mediated pro-inflammatory cytokines in vivo and in vitro. Mouse TREM-1 SCHOOL peptide has anti-tumor effects. Mouse TREM-1 SCHOOL peptide can reduce the formation of vitreoretinal neovascularization[1][2].

Product Specifications

CAS Number

[1292755-24-8]

Product Name Alternative

Mouse TREM-1 (213–221), GF9

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mouse-trem-1-school-peptide.html

Purity

99.91

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC([C@H](CC1=CC=CC=C1)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C46H78N10O12

Molecular Weight

963.17

References & Citations

[1]Sigalov AB. A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock. Int Immunopharmacol. 2014 Jul;21 (1) :208-19.|[2]Rojas MA, et al. Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy. Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864 (9 Pt B) :2761-2768.